Athletes Need to Protect Against Heat Stroke: Expert

August 25th, 2010

Heat cramps, heat exhaustion and potentially fatal heat stroke are risks when exercising or playing sports during the summer, but they can be prevented by taking a few simple precautions, advises a Medical College of Georgia expert.

Heat illness occurs when the body loses its ability to cool itself, Tim McLane, a certified athletic trainer at the MCGHealth Sports Medicine Center, said in a news release from MCGHealth. In normal conditions, the body uses sweat evaporation to cool itself during exercise. But hot, humid weather hinders sweat evaporation, which increases the risk of heat illness, he explained.

McLane offered the following safety tips:
During practices or games, alert your coach or trainer if you don’t feel well.
In order to acclimate to hot, humid conditions, gradually boost your workout intensity and duration over 10 to 14 days.
Wearing loose-fitting, light-colored clothing helps disperse body heat.
Limit strenuous exercise to early morning or late evening when temperatures are cooler. If you have to exercise in the middle of the day, limit your intensity and increase the length of your breaks.
Stay in the shade as much as possible.
Don’t take salt tablets — they may help with cramps but do not prevent heat illness.
Monitor your hydration by checking body weight. The ideal way to determine sweat loss is to weigh yourself before and after exercise.

Dehydration — a major risk factor for heat illness — can occur in as little as 30 minutes if you’re exercising in hot, humid conditions, McLane said. Athletes should drink fluids regularly because waiting until you feel thirsty may be too late. By then, you may have already lost about 2 percent of body weight as sweat.

Drink at least 16 ounces of fluid about two hours before exercise and drink at least 7 to 10 ounces of fluid every 10 to 20 minutes during exercise, McLane recommends. After exercise, drink 24 ounces per pound of body weight lost through sweat.

SOURCE: MCGHealth, news release.

Birth complications more common at night

August 17th, 2010

Picking the time of day to give birth may not be a choice very many women can make, but it could influence her chances of a smooth delivery, new research shows.

In a study of more than 700,000 births at all Dutch hospitals between 2000 and 2006, researchers found that the risks of newborn death and admission to the neonatal intensive care unit were higher with nighttime than daytime deliveries.

The findings, say the researchers, are in line with trends in other studies not only in obstetrics, but in hospital intensive care units as well.

Overall, the new study found, infants at smaller community hospitals who were born in the evening (between 6 p.m. and midnight) or overnight into early morning (between midnight and 8 a.m.) were 32 percent to 47 percent more likely to die than those born during the day.

Larger medical centers that would see more high-risk pregnancies — so-called tertiary centers – did not have as much of a difference between night and day. At these hospitals, only overnight births – as opposed to evening births — were linked to an increased risk of newborn death.

The findings were similar when the researchers looked at the risk of all adverse birth outcomes together.

But they stress that, in developed countries, serious complications are rare no matter what time of day or night a woman delivers.

“It is very important indeed to realize that risks are generally low and that the level of care in these kinds of Western countries is high,” senior researcher Dr. Eric A.P. Steegers, of Erasmus University Medical Center in Rotterdam, told Reuters Health in an e-mail.

Of the nearly 656,000 singleton births at community hospitals, between 0.05 and 0.09 percent of infants died during or soon after birth. Rates were higher among infants born at tertiary hospitals, but were still less than 1 percent.

It’s possible, Steegers said, that the increased risks reflect the fact that fewer senior staff members — including obstetricians, neonatologists and anesthesiologists — are available during night shifts.

Supporting that idea, the researchers found fewer infant deaths and complications at community hospitals when senior staff were present. At night, when such staff are at home on call, less experienced doctors may be making the initial decisions on how to manage high-risk situations.

Steegers said that more research is needed, however, to understand the extent to which hospital organization plays into the higher risk of childbirth complications at night.

It’s also possible that staff fatigue is a factor, since night-shift work is at odds with the body’s natural rhythms. But unfortunately, naps don’t seem to do the trick: It may take up to half an hour for sleepy minds to get back up to speed after a slumber, the researchers note.

Even if organizational factors at hospitals do explain the higher nighttime risks, Steegers said, it is not clear whether revamping the system would eliminate those risks.

For example, he noted, it might be possible to have senior staff available 24 hours a day if there were fewer hospitals providing obstetrics care. But fewer centers could well mean that some women would be delayed in getting to the hospital, which could increase the odds of complications.

SOURCE: http://www3.interscience.wiley.com/journal/123467987/abstract

Researchers Report Treatment Headway Against Lung Cancer

August 12th, 2010

Researchers report they prolonged survival for some patients with advanced non-small cell lung cancer, for whom the median survival is currently only about six months.

One study discovered that an experimental drug called crizotinib shrank tumors in the majority of lung cancer patients with a specific gene variant. An estimated 4 percent of lung cancer patients, or roughly 40,000 people worldwide, have this gene variant.

A second study found that a double-chemotherapy regimen benefited elderly patients, who represent the majority of those with lung cancer worldwide. Roughly 100,000 patients with lung cancer in the United States are over the age of 70.

“This is our toughest cancer in many ways,” said Dr. Mark Kris, moderator of a Saturday press conference at the annual meeting of the American Society of Clinical Oncology (ASCO), in Chicago. “It affects 220,000 Americans each year, and over a million people worldwide. Sadly, it is our nation’s — and our world’s — leading cancer.”

The first study, a phase 1 trial, found that 87 percent of 82 patients with advanced non-small cell lung cancer with a specific mutation of the ALK gene, which makes that gene fuse with another, responded robustly to treatment with crizotinib, which is made by Pfizer Inc.

“The patients were treated for an average of six months, and more than 90 percent saw their tumors shrink in size and 72 percent of participants remained progression-free six months after treatment,” said study author Dr. Yung-Jue Bang, a professor in the department of internal medicine at Seoul National University College of Medicine in South Korea. Ordinarily, only about 10 percent of patients would be expected to respond to treatment.

About half of patients experienced nausea, vomiting and diarrhea but these side effects eased over time, Bang said.

The fusion gene was first discovered to play a role in this type of lung cancer in 2007. Researchers are now working on a phase 3 trial of the drug. The Korean researchers reported financial ties to Pfizer.

“We didn’t even know this [the fusion gene] could cause lung cancer in 2006, and now we’re moving to phase 3 trials and likely pretty quick approval of this drug,” said Dr. Karen Reckamp, an assistant professor of medicine in the thoracic oncology program at City of Hope Cancer Center in Duarte, Calif. “So, although it’s only 4 percent of patients it’s still a good proportion and it will affect many lives in a significant and positive way.”

“Although this is a small proportion of the entire lung cancer population, for the few patients who have this oncogene, the drug represents enormous progress,” said Dr. Deepa Subramaniam, director of the brain tumor center at Lombardi Comprehensive Cancer Center at Georgetown University, in Washington, D.C.

Because the drug is not yet approved, testing for the gene is only available through a central lab run by Abbott Diagnostics. “Typically, testing is only done for patients who are potentially eligible for clinical trials,” she said. “Once the drug is approved, testing should become more easily available.”

The second study, a phase 3 trial, involved 451 patients with advanced non-small cell lung cancer aged 70 to 89. The study had first expected to enroll 520 patients, but it was halted early when good survival results were seen in the group taking the combination therapy.

Currently, elderly patients are typically given just one chemotherapy drug, with younger patients more likely to get two or more.

“The elderly have been very understudied in lung cancer studies, despite the fact that the median age for getting lung cancer is about 70. The median age for most trials is well under that,” said Reckamp. “This is the first randomized trial in patients aged 70 to almost 90.”

Previous studies had been mixed and had serious side effects, she added. “There is definitely increased toxicity, but [this study shows] it is probably manageable in most patients.”

In this trial, participants were randomly selected to receive either one chemotherapy agent — gemcitabine (Gemzar) or vinorelbine (Navelbine) — or to receive both carboplatin and paclitaxel (Taxol).

For the single-agent group, median survival at one year was 6.2 months and 27 percent patients were still alive, “which is consistent with previous research,” said study author Dr. Elisabeth Quoix, a professor of medicine at University Hospital in Strasbourg, France.

“In the double-therapy group, the median survival increased by four months [to 10.3 months], which is quite unusual in thoracic oncology,” Quoix said. “Forty-five percent of patients survived one year, which is also quite unusual.”

“The four-month improvement is a huge one,” added Kris, who is chief of thoracic oncology at Memorial Sloan-Kettering Cancer Center in New York City. “Other large clinical trials … have generally felt to be practice-changing with a two-month change in median survival. This trial supports the idea that patients over 70 should be treated just as anyone else.”

“I don’t think this will result in an immediate change in practice,” said Subramaniam. “This reinforces the fact that physiological age matters as much as chronological age.”

Quoix and other study authors reported ties with different pharmaceutical companies, including Eli Lilly Co. and Roche Inc.

Finally, a phase 3 study out of the University of Texas M.D. Anderson Cancer Center in Houston found patients receiving the targeted drug vandetanib combined with chemotherapy had a 21 percent decline in disease progression compared to those receiving chemotherapy alone. Median progression-free survival in the combination arm was 17.3 weeks vs. 14 weeks in the control group.

This study was simultaneously presented Saturday at the ASCO meeting and published in The Lancet Oncology.

Kris also reported ties with several pharmaceutical firms.

SOURCES: 2010, teleconference with Mark G. Kris, M.D., chief, thoracic oncology service, Memorial Sloan-Kettering Cancer Center, New York City; Elisabeth Quoix, M.D., professor, medicine, University Hospital, Strasbourg, France; Yung-Jue Bang, M.D., Ph.D., professor, department of internal medicine, Seoul National University College of Medicine, Seoul, South Korea; Karen Reckamp, M.D., assistant professor, medicine, thoracic oncology program, City of Hope Cancer Center, Duarte, Calif.; Deepa Subramaniam, M.D., director, brain tumor center, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.

Low vitamin D tied to depression in older people

July 29th, 2010

Older men and women with lower levels of vitamin D in their blood are more prone to become depressed over time, new research shows.

Many studies have been published recently on the potential health benefits of vitamin D, and the potential risks of deficiency. Low vitamin D levels have been linked to heart disease, stroke, high blood pressure, and more severe asthma.

In older people, insufficient vitamin D is quite common, and has been linked to fractures, worse physical function, greater frailty, and a wide variety of chronic illness.

In the current study, Dr. Luigi Ferrucci of the National Institute on Aging in Baltimore and colleagues looked at whether low vitamin D levels and depression in older people might be related.

They followed 531 women and 423 men 65 and older who were participating in the InCHIANTI Study, a long-term investigation of factors associated with loss of mobility in aging people, over six years.

At the study’s outset, 42 percent of the women and 18 percent of the men were depressed, while three-quarters of the women and half of the men had levels of vitamin D below 50 nanomoles per liter, which is generally considered insufficient.

Seventy-two percent of the depressed people and 60 percent of the non-depressed people had vitamin D insufficiency – the level above deficiency — the researchers found. Women with vitamin D insufficiency showed a worse decline in mood at three and six years into the study; their scores on a standardized test measuring depressive symptoms increased more at three and six years compared to the scores for women who had adequate vitamin D. This increase could have tipped the scale into a diagnosis of depression for some people.

Women with low vitamin D who weren’t depressed at the beginning of the study were also twice as likely to become depressed over the following six years as the women who had sufficient levels of the nutrient. While similar patterns were seen for men, the association wasn’t as strong, and in some cases could have been due to chance, according to the researchers.

The study does not prove that low vitamin D levels cause depression, the authors note; people with low levels of the nutrient might have other characteristics that predispose them to the blues.

Still, they suggest that preventing “vitamin D deficiency in the elderly may become in the future a strategy to prevent the development of depressive mood in the elderly and avoid its deleterious consequences on health. In addition, normalization of vitamin D levels may be part of any depression treatment plans in older patients.”

Vitamin D, produced by the body when skin is exposed to sunlight, is also found in certain foods such as oily fish. It helps cells absorb calcium and is important for bone health.

However, the authors conclude, before any strategies to boost vitamin D can be adopted they must be tested in larger and more rigorously designed trials.

SOURCE: http://jcem.endojournals.org/cgi/content/abstract/jc.2010-034 7v1 Journal of Clinical Endocrinology and Metabolism.

Are taller men at greater risk of blood clots?

July 21st, 2010

Men who are six feet tall or taller may have a higher risk of blood clots in their veins than do their shorter counterparts, while height does not seem to have an impact on women’s risk, a new study suggests.

The blood clots, known as venous thromboembolisms, include clots in the deep veins — usually in the legs — and pulmonary embolism, a potentially fatal condition that occurs when a deep-vein blood clot travels to the lungs.

Certain situations can lead to clots in some people, such as being immobilized after surgery or taking a long-haul flight. There are also lifestyle-related factors, such as obesity and smoking, which can leave a person more vulnerable to the blood clots.

Some studies have found a correlation between height and clot risk, with greater height equaling greater risk. But those studies have only included men.

In the new study, of nearly 27,000 Norwegian adults followed for 12 years, researchers confirmed an association between height and clots among men, but found no similar pattern among women.

Overall, the tallest men — those who were taller than 181 centimeters, or roughly 6 feet — had double the clot risk of men who were shorter than 173 centimeters, or 5 feet, 8 inches. That was with factors such as weight, smoking habits and diabetes taken into account.

The findings, reported in the American Journal of Epidemiology, do not prove that greater height itself is a risk factor for clots.

The researchers accounted for a number of factors that could have explained the link, but there may be other variables at work that were unmeasured in the study, according to lead researcher Dr. Sigrid K. Brakken, of the University of Tromso in Norway.

However, Brakken told Reuters Health by email, it is plausible that taller height could affect the odds of blood clots in the veins — due to what’s known as “venous stasis,” or slowed blood flow in the veins, particularly those of the legs. That slower flow increases the potential for blood clotting.

The reason the association is seen only in men, according to Brakken, is likely because fewer women are tall enough for their height to affect clot risk.

The findings are based on data from 26,727 Norwegians between the ages of 25 and 96 who were followed for 12 years. During that time, 462 developed a first-time clot; they were often related to specific causes, like surgery, trauma or medical conditions such as cancer — but in 42 percent of cases, there were no such “provoking” factors.

Among men who stood at six feet or taller, there were 1.68 clots per 1,000 men per year. That compared with a rate of 0.84 per 1,000 men per year among those who were shorter than 5 foot 8.

When the researchers accounted for weight and several other factors that affect clot risk, the tallest men still had double the risk of the shortest men.

If further research confirms that greater height is a risk factor for clots, Brakken said, it could help identify those people who need to take steps to prevent the blood clots.

Not smoking, losing excess weight and getting regular exercise are among the ways to lower clot risk.

Vaccine may trigger early start of infant epilepsy

July 14th, 2010

Childhood vaccines may trigger early onset of a severe form of infant epilepsy, but researchers say the disorder is ultimately caused by defective genes and lifesaving vaccines should not be withheld from these children.

The researchers said they feared the study published in the Lancet medical journal would scare parents away from getting their children vaccinated but stressed the babies in the study would likely have developed seizures within months regardless of the vaccine.

The disorder, called Dravet syndrome, generally begins with seizures around six months of age. These children have poor language and motor skills and difficulty relating to others.

Up to 80 percent of them have mutations in the SCN1A gene.

Anne McIntosh of the University of Melbourne’s Epilepsy Research Center and colleagues examined the medical records of 40 Dravet syndrome patients with the genetic mutation who had been vaccinated against whooping cough, or pertussis.

They said 30 percent of these children developed their first seizures within two days of receiving the vaccine but symptoms of their disorder were no worse than the other children who had their first seizures later on.

“In about 30 percent of people, it appears that (first seizures) came on rather quickly after the vaccination. But the overall message is that the outcome to the patients did not differ regardless of whether the onset of the disorder was shortly after the vaccination, or later on,” said McIntosh.

“These kids already had that genetic abnormality, (so) regardless of the relationship with the vaccine, they would have actually had that disorder happen to them anyway,” she added.

“Essentially, there is no proof that people should not be vaccinated … from concerns about it causing the onset of that disease,” she said in a telephone interview.

SENSITIVE ISSUE

Reports linking childhood vaccines to any sort of disorder are always sensitive because they can result in parents refusing to get their children vaccinated. This has caused a resurgence of dangerous diseases, including mumps, measles and whooping cough, in Britain, the United States and elsewhere.

In 1998 British doctor Andrew Wakefield published a study in The Lancet, suggesting the combined measles, mumps and rubella or MMR vaccine might be linked to autism and bowel disease.

The assertion has been widely discredited for years, the Lancet has withdrawn the paper and Britain’s General Medical Council has ruled Wakefield acted dishonestly and irresponsibly.

But the damage has been done — the number of MMR vaccinations in the United States and Europe plunged, prompting a resurgence of both measles and mumps.

This Australian study by McIntosh and colleagues follows an earlier investigation into whether the pertussis vaccine, which is routinely given to children together with diphtheria and typhoid vaccines (DTP), may have led to cases of encephalopathy.

The earlier investigation, led by Samuel Berkovic of the Epilepsy Research Center at the University of Melbourne, found that 12 of 14 patients with so-called vaccine encephalopathy were actually suffering from Dravet syndrome. Eleven of these 12 children were also found to have the SCN1A gene variant.

In an accompanying commentary, Max Wiznitzer from the Rainbow Babies & Children’s Hospital in Cleveland, Ohio, said McIntosh’s study was “consistent with the conclusion that outcome is determined by the underlying disorder and not by proximity to vaccine administration.”

Wiznitzer, who was not involved in the study, said “effective and accurate information and communication” could help maintain public confidence in vaccines.

(Editing by Maggie Fox and Krittivas Mukherjee)
Reuters Health

Moderate drinking helps young people’s hearts too

July 6th, 2010

Moderate drinking cuts heart disease risk in younger adults, new research shows.

However, young adults are at low risk for heart disease, the researchers point out in the journal Circulation, “and the beneficial effects obtained by a moderate alcohol intake may be negligible compared with the increased risk of, for instance, traffic accidents and cancer.”

Moderate drinking — typically defined as a drink or two a day — can be heart healthy in older men and women, although heavy drinking does not protect the heart, and carries many other health risks.

Because heart disease is so rare in men under 40 and women under 50, it has been difficult to study the effects of alcohol consumption on heart disease risk in these younger individuals.

To address this problem, Dr. Alberto Ascherio of the Harvard School of Public Health in Boston and colleagues pooled data from eight studies from North America and Europe that included over 192,000 women and nearly 75,000 men. The men’s average age was around 50, while the average age for women was 54. At the study’s outset, all of the participants were free from cardiovascular disease, and all had reported their alcohol drinking habits.

Overall, Ascherio and his colleagues found, consuming 30 grams of alcohol a day (about two or three standard drinks) reduced women’s risk of developing heart disease by 42 percent, and cut men’s risk by 31 percent. When the researchers broke the study participants into three age categories — those 50 and under, those 50 to 59, and people 60 and older — they saw the same pattern of reduced risk with moderate drinking in each age group.

Given that the risk of heart disease is so low in younger people, Ascherio and his colleagues say, the protective effects of alcohol are likely to be stronger in older people at higher risk of heart problems. However, all possible health risks of alcohol need to be taken into account when developing guidelines on alcohol consumption for people of different ages, they conclude.

SOURCE: Circulation

Mammograms May Not Boost Survival, Danish Study Suggests

June 21st, 2010

Screening women for breast cancer does not appear to increase overall survival from the disease, a new study finds.

The increased survival rates may instead be due to controlling risk factors and improved treatments, the researchers suggest.

“Mammography screening is not as good as we hoped years ago,” said study author Dr. Karsten Jorgensen, a researcher at the Nordic Cochrane Centre in Copenhagen, Denmark.

“It is questionable if it saves women from dying from breast cancer, but we are certain that it has serious harms such as overdiagnosis and overtreatment of lesions that would otherwise never have caused problems, unnecessary recalls with long-term psychological consequences, and unnecessary biopsies and worries,” Jorgensen added.

The report is published in the March 24 online edition of the BMJ.

For the study, Jorgensen’s team compared the changes in death rates from breast cancer in two Danish screening programs with areas in Denmark that do not screen women for breast cancer. They looked at the 10-year period after screening would be expected to have an effect on breast cancer deaths and compared that with the 10-year period before screening was started.

In addition, they looked at three age groups: women aged 55 to 74, who would benefit from screening; women aged 35 to 55, who were too young to have benefited from screening; and women aged 75 to 84, who were too old to have seen an effect from screening.

“In the age group that could benefit from screening mammography, breast cancer mortality in Danish regions that did not offer mammography screening decreased similar or more than in those regions that did [offer mammography],” Jorgensen said.

Jorgensen’s group found among women aged 55 to 74, breast cancer deaths dropped by 1 percent per year in the screened areas, compared with 2 percent per year in the non-screened areas. Among women aged 35 to 54, deaths from breast cancer dropped by 5 percent per year in the screened areas and 6 percent per year in the non-screened areas. For women aged 75 to 84, there was no significant change in breast cancer mortality either with screened or non-screened areas, the researchers noted.

“The decline in breast cancer mortality began years before the mammography screening program did, and the declines in breast cancer mortality were much larger in age groups too young to benefit than in the age groups that could,” Jorgensen said. “The absence of an effect of screening mammography in population statistics is clearly contrary to expectations, and our findings speak against screening mammography being effective.”

So, it is not clear-cut that mammography screening saves lives, Jorgensen said. The same researchers reported previously in the same journal that one of three breast cancers detected by mammograms never cause a problem, possibly regressing on their own without treatment.

“Similar to our study, breast cancer mortality in the U.S. has declined much more in women below 50 years than in women over 50 years, where the expected effect and screening coverage is larger. It is time to dare to ask the critical questions about screening mammography that has been avoided for many years. We may not like what we find, but it is the only right thing to do,” Jorgensen said.

However, Robert Smith, director of cancer screening at the American Cancer Society, couldn’t disagree more with that conclusion.

“The main problem with their analysis is that it is over a short period of time, and they are not able to isolate deaths attributable to cases diagnosed in the pre-screening period,” he said.

Mammography does save lives, Smith said. The ability to diagnose breast cancer early is a major reason the deaths from breast cancer have declined, he said.

Smith agrees that prevention strategies and better treatment have also saved the lives of women with breast cancer. “But they pale to the contribution of screening,” he said.

SOURCES: Karsten Jorgensen, M.D., Nordic Cochrane Centre, Rigshospitalet Department, Copenhagen, Denmark; Robert Smith, Ph.D., director, cancer screening, American Cancer Society, Atlanta; BMJ, online

Many WTC Responders Show Signs of Heart Trouble

June 3rd, 2010

Police who responded on 9/11 to the collapsing World Trade Center towers appear to be at greater risk for heart problems compared with people in the general population, a new study finds.

The report was to be presented Saturday at the American College of Cardiology’s annual meeting, in Atlanta.

“This is the first study to suggest a potential link between exposure to Ground Zero and early preclinical heart abnormalities,” lead researcher Dr. Lori Croft, an assistant professor of medicine at Mount Sinai School of Medicine in New York City, said in an ACC news release.

“Inhaled particulate matter has been shown to cause lung and heart disease. Exposure to the dust from the collapsed buildings may play a role in these cardiac abnormalities,” she said.

For the study, Croft’s team looked at the heart function of almost 1,200 police officers who were observed at Mount Sinai Medical Center as part of a program to assess cardiovascular health after the Sept. 11, 2001 terrorist attack. The officers underwent ultrasound screening from January 2008 through June 2009.

The research team looked in particular at a condition called diastolic dysfunction. This occurs when the lower chambers of the heart — the ventricles — become stiff and cannot fully relax during the pumping stage called diastole, when the ventricles fill with blood. The result is that blood can back up into the lungs, reducing lung capacity.

Croft’s group found that more than 60 percent of the officers had less-than-normal diastolic heart function. When the researchers looked only at those under 50 years of age, 47 percent still had diastolic dysfunction. These percentages are much higher than what’s found in the general population, where about 7 percent suffer from diastolic dysfunction.

The researchers stressed that these results must be confirmed, and other factors, such as stress in the aftermath of events like 9/11, can also affect the heart. In addition, they said these findings need to be compared with other police officers who work in polluted urban areas and undergo job-related stress.

“Additional research is needed to determine if there is a link between early exposure to the World Trade Center collapse and heart function among law enforcement personnel,” Croft said. “Our findings may also be related to the daily stress of working in law enforcement, as well as exposure to [baseline] urban pollution. More studies are needed to understand and tease out the clinical significance of short- and long- term consequences of these findings.”

However, the study results add to growing evidence that exposure to the collapse of the World Trade Center was the cause of health problems. Other studies have linked lung damage, asthma and post-traumatic stress disorder to the event, the researchers noted.

The study was paid for by the Fraternal Order of Police of New York State, through an agreement from the New York State Attorney General Charities Bureau.

The results of another study, also to be presented Saturday at the meeting, found that police officers and firefighters are two to four times more likely to have heart attacks or sudden cardiac death while working, compared with the general population.

The study, led by Dr. M. Zubair Jafar, director of the Cardiac Cath Lab and the Cardiac Research Program at the Hudson Valley Heart Center in Fishkill, N.Y., found that the increased risk was more likely due to job stress rather than blocked coronary arteries.

The researchers came to their conclusion by measuring calcium scores in 717 police officers and firefighters and comparing them with scores of 449 people not in these professions.

Jafar’s team found that both groups had similar calcium scores. Measuring calcium levels in blood vessels is one way of telling how badly arteries are constricted. This constriction can be a predictor of heart attack and cardiac arrest.

Since the calcium scores were equal between the two groups, the researchers now speculate that job stress can cause cholesterol plaque in the artery to rupture, causing a heart attack. Among police and firefighters, cardiac events are the most frequent cause of on-duty death, more than burns or other injuries, Jafra’s group noted.

SOURCES:  2010, presentations, American College of Cardiology annual meeting, Atlanta

Shortage of Black Doctors Rooted in Social, Economic Ills

May 21st, 2010

A lack of black doctors in the United States can be traced to social and economic problems that predate the college years, new research suggests.

As of 2005, less than 8 percent of first-year medical students in the United States were black, even though blacks account for about 15 percent of the U.S. population.

For this study, researchers examined National Longitudinal Study data on more than 13,000 Americans who graduated from high school in 1972, including about 1,450 blacks. The participants were tracked into their 30s. The representation of blacks declined from 11 percent at high school graduation to 9 percent at college entry to 7.2 percent at college graduation, down to 4.1 percent at the stage of entry into health professions, such as physicians, therapists, dentists, registered nurses, pharmacists, psychologists, optometrists and dietitians.

Most of the disparity in the number of blacks and whites entering health professions can be traced to factors that occurred much earlier in the educational system, including parents’ education level, students’ attending schools with lower per-pupil spending, high poverty rates and lower average scores on standardized tests, the researchers determined.

“The flow of blacks into the health care professions has been reduced at an early stage in the educational pipeline, so we must go back in the pipeline to open up that spigot,” lead author Jessica Howell, an associate professor of economics at California State University in Sacramento, said in a news release. “This research and other research confirm that you have to go back further in the pipeline than many people realize.”

The study was published in the Winter 2010 issue of the Journal of Human Resources.

Besides boosting the number of blacks in health care professions, narrowing the pre-college educational gaps between blacks and whites would lead to more blacks in other professions, such as law and business management, said Howell, who conducted the research while she was a visiting professor at the University of Virginia.

SOURCE: University of Virginia, news release.